| Date | Location | Result | |
| 11/26/10 | Akron, Ohio | Akron 22, Buffalo 14 | Box score |
| Nov 20, 2010 | Buffalo, NY | Eastern Michigan 21, Buffalo 17 | Box score |
| Nov 12, 2010 | Buffalo, NY | Ball State 20, Buffalo 3 | Box score |
| Nov 04, 2010 | Athens, Ohio | Ohio 34, Buffalo 17 | Box score |
| Oct 30, 2010 | Buffalo, NY | Miami 21, Buffalo 9 | Box score |
| Oct 23, 2010 | Buffalo, NY | Temple 42, Buffalo 0 | Box score |
| Oct 16, 2010 | DeKalb, Ill. | Northern Illinois 45, Buffalo 14 | Box score |
| Oct 02, 2010 | Bowling Green, Ohio | Buffalo 28, Bowling Green 26 | Box score |
| Sep 25, 2010 | East Hartford, Conn. | Connecticut 45, Buffalo 21 | Box score |
| Sep 18, 2010 | Buffalo. NY | UCF 24, Buffalo 10 | Box score |
| Sep 11, 2010 | Waco, Texas | Baylor 34, Buffalo 6 | Box score |
| Sep 02, 2010 | Buffalo, NY | Buffalo 31, Rhode Island 0 | Box score |